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KMID : 0984920010030010026
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Journal of Skin Barrier Research
2001 Volume.3 No. 1 p.26 ~ p.34
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Effect of Ionic Astrigents in the Iontophoresis
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Shin Byung-Cheol
Kim Jae-Hong
Kim Sung-Soo
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Abstract
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The effect of astrigents on the iontophoretic delivery was studied. We delivered lidocaine through the hairless mouse skin using diffusion cell and investigated the effect of the amount of cation salts such as sodium chloride, calcium acetate,
zinc acetate and aluminum acetate on the iontophoresis. The amounts of drugs and metal ions after iontophoresis were measured by HPLC and AAS(Atomic Absorption Spectrophotometry), respectively .The addition of zinc acetate and aluminum greatly enhanced the delivery of lidocaine. The detection two metal ions by AAS seemed to support the idea that the astringency effect of these ions were the main reason for the enhancement of transdermal delivery.
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KEYWORD
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lidocaine, iontophoresis, astringency, ionic enhancer
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